This is interesting to me, from Psalm 105:25:
"He turned their heart to hate his people, to deal subtilly with his servants."
It is in reference to the Israelites just before they left Egypt to return to the Promised Land, just before the ten plagues on Egypt. They had been comfortable; the Egyptians liked them, and they liked the Egyptians. It was convenient, but they weren't supposed to be in Egypt.
So God orchestrated some events, and according to this verse, even turned the heart of the Egyptians to hate the Israelites. This working in the hearts of the Egyptians and the Israelites prompted the necessary change that moved the Israelites back to where God had called them to go.
What uncomfortable relationship is in your life right now? Is God trying to use it to push you towards Him? Maybe those unkind or unfair things that are happening to you are actually gifts from God to move you from a convenient relationship with Him to an obedient, personal relationship with Him, fully committed and dependent upon His leadership.